Stress is a significant contributor to abdominal pain because it heightens the body’s physiological response, increasing gut sensitivity, altering motility, and amplifying inflammation signals. When stress hormones rise, the brain–gut axis becomes dysregulated, leading many individuals to experience cramps, bloating, or discomfort even without underlying disease. Chronic stress can also exacerbate functional gastrointestinal disorders, making symptoms more persistent. While treatments vary depending on the root cause, medications such as mebendazole 500mg are used only for specific parasitic infections and are not intended for stress-related pain. Effective management typically requires a combination of stress reduction, behavioral strategies, and clinical evaluation.